3CDZ

Crystal structure of human factor VIII

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Coagulation factor VIII heavy chain	polymer	754	86455.7	1	UniProt (P00451) Pfam (PF07732)	Homo sapiens (human)	Procoagulant component, Antihemophilic factor, AHF, Factor VIIIa heavy chain, 92 kDa isoform
2	B (B)	Coagulation factor VIII light chain	polymer	684	79050.6	1	UniProt (P00451) Pfam (PF07731) Pfam (PF00754)	Homo sapiens (human)	Procoagulant component, Antihemophilic factor, AHF, Factor VIII B chain, Factor VIIIa light chain
3	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D (D)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		707.6	1	In PDB GlyTouCan (G95760DN)
5	E, I (A, B)	COPPER (II) ION	non-polymer		63.5	2	Chemie (CU)
6	F (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
7	G, H (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 1 - 740 (UniProt: P00451)

PDB	External Database	Details
Ser 741	-	SEE REMARK 999
Phe 742	-	SEE REMARK 999
Ser 743	-	SEE REMARK 999
Gln 744	-	SEE REMARK 999
Asn 745	-	SEE REMARK 999
Pro 746	-	SEE REMARK 999
Pro 747	-	SEE REMARK 999
Val 748	-	SEE REMARK 999
Leu 749	-	SEE REMARK 999
Lys 750	-	SEE REMARK 999
Arg 751	-	SEE REMARK 999
His 752	-	SEE REMARK 999
Gln 753	-	SEE REMARK 999
Arg 754	-	SEE REMARK 999

B: 1649 - 2332 (UniProt: P00451)

PDB	External Database	Details
Leu 1880	Phe 1899	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	165506.3
Branched	Number of molecules	2
	Total formula weight	1132.0
Non-Polymers*	Number of molecules	5
	Total formula weight	609.6
All*	Total formula weight	167248.0

*Water molecules are not included.