3BN3
crystal structure of ICAM-5 in complex with aL I domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Integrin alpha-L | polymer | 180 | 20532.5 | 1 | UniProt (P20701) Pfam (PF00092) In PDB | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a antigen |
| 2 | B | Intercellular adhesion molecule 5 | polymer | 196 | 22115.3 | 1 | UniProt (Q9UMF0) Pfam (PF03921) In PDB | Homo sapiens (human) | ICAM-5; Telencephalin |
| 3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 226 | Chemie (HOH) |
Sequence modifications
A: 129 - 307 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Met 128 | - | initiating methionine |
| Trp 189 | Arg 214 | variant |
| Ser 265 | Phe 290 | engineered mutation |
| Gly 292 | Phe 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42647.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1093.3 | |
| All* | Total formula weight | 44165.6 |
