3BIC

Crystal structure of human methylmalonyl-CoA mutase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methylmalonyl-CoA mutase, mitochondrial precursor	polymer	762	84835.8	2	UniProt (P22033) Pfam (PF01642) Pfam (PF02310)	Homo sapiens (human)	MCM, Methylmalonyl-CoA isomerase
2	C, D, E, F (A, B)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
3	G, H (A, B)	water	water		18.0	84	Chemie (HOH)

Sequence modifications

A, B: 12 - 750 (UniProt: P22033)

PDB	External Database	Details
Met 11	-	expression tag
Thr 499	Ala 499	variant
Ala 751	-	expression tag
Glu 752	-	expression tag
Asn 753	-	expression tag
Leu 754	-	expression tag
Tyr 755	-	expression tag
Phe 756	-	expression tag
Gln 757	-	expression tag
Ser 758	-	expression tag
His 759	-	expression tag
His 760	-	expression tag
His 761	-	expression tag
His 762	-	expression tag
His 763	-	expression tag
His 764	-	expression tag
Asp 765	-	expression tag
Tyr 766	-	expression tag
Lys 767	-	expression tag
Asp 768	-	expression tag
Asp 769	-	expression tag
Asp 770	-	expression tag
Asp 771	-	expression tag
Lys 772	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	169671.6
Non-Polymers*	Number of molecules	4
	Total formula weight	141.8
All*	Total formula weight	169813.5

*Water molecules are not included.