3BIC
Crystal structure of human methylmalonyl-CoA mutase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016866 | molecular_function | intramolecular transferase activity |
| A | 0019678 | biological_process | propionate metabolic process, methylmalonyl pathway |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050667 | biological_process | homocysteine metabolic process |
| A | 0072341 | molecular_function | modified amino acid binding |
| A | 1901290 | biological_process | succinyl-CoA biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0009791 | biological_process | post-embryonic development |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016866 | molecular_function | intramolecular transferase activity |
| B | 0019678 | biological_process | propionate metabolic process, methylmalonyl pathway |
| B | 0031419 | molecular_function | cobalamin binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043547 | biological_process | positive regulation of GTPase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050667 | biological_process | homocysteine metabolic process |
| B | 0072341 | molecular_function | modified amino acid binding |
| B | 1901290 | biological_process | succinyl-CoA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 803 |
| Chain | Residue |
| A | SER594 |
| A | LYS595 |
Functional Information from PROSITE/UniProt
| site_id | PS00544 |
| Number of Residues | 26 |
| Details | METMALONYL_COA_MUTASE Methylmalonyl-CoA mutase signature. RIARNTqiIIqEEsgipKvaDPwGGS |
| Chain | Residue | Details |
| A | ARG403-SER428 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20876572 |
| Chain | Residue | Details |
| A | GLN50 | |
| B | TYR96 | |
| B | THR106 | |
| B | THR216 | |
| B | ARG228 | |
| B | LYS255 | |
| B | HIS265 | |
| B | ARG304 | |
| A | TYR96 | |
| A | THR106 | |
| A | THR216 | |
| A | ARG228 | |
| A | LYS255 | |
| A | HIS265 | |
| A | ARG304 | |
| B | GLN50 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20876572 |
| Chain | Residue | Details |
| A | HIS627 | |
| B | HIS627 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P16332 |
| Chain | Residue | Details |
| A | LYS89 | |
| A | LYS212 | |
| A | LYS335 | |
| A | LYS602 | |
| B | LYS89 | |
| B | LYS212 | |
| B | LYS335 | |
| B | LYS602 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P16332 |
| Chain | Residue | Details |
| A | LYS343 | |
| A | LYS595 | |
| B | LYS343 | |
| B | LYS595 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER481 | |
| B | SER481 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| A | HIS627 | |
| A | ASP625 | |
| A | HIS678 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| B | HIS627 | |
| B | ASP625 | |
| B | HIS678 |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| A | LYS621 | |
| A | HIS265 | |
| A | HIS627 | |
| A | TYR110 | |
| A | ASP625 |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| B | LYS621 | |
| B | HIS265 | |
| B | HIS627 | |
| B | TYR110 | |
| B | ASP625 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| A | PHE638 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1bmt |
| Chain | Residue | Details |
| B | PHE638 |
