3AVR
Catalytic fragment of UTX/KDM6A bound with histone H3K27me3 peptide, N-oxyalylglycine, and Ni(II)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 6A | polymer | 531 | 60264.4 | 1 | UniProt (O15550) Pfam (PF02373) Pfam (PF21322) Pfam (PF21326) | Homo sapiens (human) | Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein |
| 2 | B (B) | Histone H3 | polymer | 22 | 2313.8 | 1 | UniProt (by SIFTS) (P68431) | ||
| 3 | C (A) | N-OXALYLGLYCINE | non-polymer | 147.1 | 1 | Chemie (OGA) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 6 | F, G, H, I, J... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 7 | O, P (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 8 | Q, R (A, B) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A: 880 - 1401 (UniProt: O15550)
| PDB | External Database | Details |
|---|---|---|
| Gly 871 | - | expression tag |
| Pro 872 | - | expression tag |
| Gly 873 | - | expression tag |
| Tyr 874 | - | expression tag |
| Gln 875 | - | expression tag |
| Asp 876 | - | expression tag |
| Pro 877 | - | expression tag |
| Asn 878 | - | expression tag |
| Ser 879 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62578.2 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 900.7 | |
| All* | Total formula weight | 63478.9 |
