3QRF
Structure of a domain-swapped FOXP3 dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (N, M) | Nuclear factor of activated T-cells, cytoplasmic 2 | polymer | 286 | 32209.7 | 2 | UniProt (Q13469) Pfam (PF00554) Pfam (PF16179) | Homo sapiens (human) | NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-ATp, T-cell transcription factor NFAT1 |
| 2 | B, C, G, H (F, G, H, I) | Forkhead box protein P3 | polymer | 82 | 10082.7 | 4 | UniProt (Q9BZS1) Pfam (PF00250) | Homo sapiens (human) | Scurfin |
| 3 | D, I (C, A) | human hARRE2 DNA (Plus Strand) | polymer | 21 | 6491.2 | 2 | |||
| 4 | E, J (D, B) | human hARRE2 DNA (Minus Strand) | polymer | 21 | 6389.2 | 2 | |||
| 5 | K, L, M, N (F, G, H, I) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | O, P, Q, R (N, C, D, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
N, M: 396 - 678 (UniProt: Q13469)
| PDB | External Database | Details |
|---|---|---|
| Ser 393 | - | expression tag |
| Ser 394 | - | expression tag |
| Val 395 | - | expression tag |
| Ala 629 | Asp 629 | conflict |
| Ala 630 | Lys 630 | conflict |
| Ala 631 | Asp 631 | conflict |
| Ala 632 | Lys 632 | conflict |
| Ala 633 | Ser 633 | conflict |
| Ala 634 | Gln 634 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 130511.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 97.2 | |
| All* | Total formula weight | 130608.4 |
