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2ZMF

Crystal structure of the C-terminal GAF domain of human phosphodiesterase 10A

Replaces:  2E4S
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer18921476.72UniProt (Q9Y233)
Pfam (PF01590)
Homo sapiens (human)
2C, D
(A, B)
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATEnon-polymer329.22Chemie (CMP)
3E, F
(A, B)
waterwater18.0168Chemie (HOH)
Sequence modifications
A, B: 246 - 427 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 239-expression tag
Ser 240-expression tag
Ser 241-expression tag
Gly 242-expression tag
Ser 243-expression tag
Ser 244-expression tag
Gly 245-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight42953.5
Non-Polymers*Number of molecules2
Total formula weight658.4
All*Total formula weight43611.9
*Water molecules are not included.

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PDB entries from 2026-02-25

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