2Z5S

Molecular basis for the inhibition of p53 by Mdmx

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E (M, N, O)	Mdm4 protein	polymer	140	15661.6	3	UniProt (Q4V944) Pfam (PF02201) UniProt (by SIFTS) (Q7ZUW7)	Danio rerio (zebrafish)	Zebrafish MDMX
2	B, D, F (P, Q, R)	Cellular tumor antigen p53	polymer	15	1808.0	3	UniProt (P04637) Pfam (PF08563)		Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
3	G, H, I, J, K... (M, P, N, Q, O...)	water	water		18.0	147	Chemie (HOH)

Sequence modifications

M, N, O: 15 - 140 (UniProt: Q4V944)

PDB	External Database	Details
Met 488	-	expression tag
Ala 489	-	expression tag
His 490	-	expression tag
His 491	-	expression tag
His 492	-	expression tag
His 493	-	expression tag
His 494	-	expression tag
His 495	-	expression tag
Asp 496	-	expression tag
Asp 497	-	expression tag
Asp 498	-	expression tag
Asp 499	-	expression tag
Lys 500	-	expression tag
Ile 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	52408.8
All*	Total formula weight	52408.8

*Water molecules are not included.