2Z5S

Molecular basis for the inhibition of p53 by Mdmx

Functional Information from GO Data

Chain	GOid	namespace	contents
M	0005634	cellular_component	nucleus
M	0043066	biological_process	negative regulation of apoptotic process
M	0051726	biological_process	regulation of cell cycle
N	0005634	cellular_component	nucleus
N	0043066	biological_process	negative regulation of apoptotic process
N	0051726	biological_process	regulation of cell cycle
O	0005634	cellular_component	nucleus
O	0043066	biological_process	negative regulation of apoptotic process
O	0051726	biological_process	regulation of cell cycle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	249
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Motif: {"description":"TADI"}

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine; by CK1, VRK1 and VRK2","evidences":[{"source":"PubMed","id":"10606744","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10951572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16704422","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]}

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by CHEK2, CK1 and PLK3","evidences":[{"source":"PubMed","id":"10570149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11447225","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11551930","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12810724","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20041275","evidenceCode":"ECO:0000269"}]}

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"21597459","evidenceCode":"ECO:0000269"}]}

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