2YN8
ephB4 kinase domain inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | EPHRIN TYPE-B RECEPTOR 4 | polymer | 298 | 33531.3 | 2 | UniProt (P54760) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | HEPATOMA TRANSMEMBRANE KINASE, TYROSINE-PROTEIN KINASE TYRO11 |
| 2 | C, D (A, B) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 419 | Chemie (HOH) |
Sequence modifications
A, B: 598 - 892 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Gly 595 | - | expression tag |
| Ser 596 | - | expression tag |
| Ser 597 | - | expression tag |
| Glu 774 | Tyr 774 | engineered mutation |
| Val 803 | Ala 803 | engineered mutation |
| Ile 870 | Val 870 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67062.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 933.1 | |
| All* | Total formula weight | 67995.7 |
