2YHO

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	E3 UBIQUITIN-PROTEIN LIGASE MYLIP	polymer	79	8861.4	4	UniProt (Q8WY64) Pfam (PF13920) In PDB	HOMO SAPIENS (HUMAN)	INDUCIBLE DEGRADER OF THE LDL-RECEPTOR, IDOL, MYOSIN REGULATORY LIGHT CHAIN INTERACTING PROTEIN, MIR
2	B, D, F, H	UBIQUITIN-CONJUGATING ENZYME E2 D1	polymer	149	16750.1	4	UniProt (P51668) Pfam (PF00179) In PDB	HOMO SAPIENS (HUMAN)	STIMULATOR OF FE TRANSPORT, SFT, UBC4/5 HOMOLOG, UBCH5, UBIQUITIN CARRIER PROTEIN D1, UBIQUITIN-CONJUGATING ENZYME E2(17)KB 1, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 1, UBIQUITIN-PROTEIN LIGASE D1, UBE2D1
3	A, C, E, G	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4	A, B, F, G, H	ACETATE ION	non-polymer		59.0	9	Chemie (ACT)
5		water	water		18.0	406	Chemie (HOH)

Sequence modifications

A, C, E, G: 369 - 445 (UniProt: Q8WY64)

PDB	External Database	Details
Gly 367	-	expression tag
Ala 368	-	expression tag

B, D, F, H: 1 - 147 (UniProt: P51668)

PDB	External Database	Details
Gly -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	102446.2
Non-Polymers*	Number of molecules	17
	Total formula weight	1054.7
All*	Total formula weight	103500.9

*Water molecules are not included.