2YHO
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | E3 UBIQUITIN-PROTEIN LIGASE MYLIP | polymer | 79 | 8861.4 | 4 | UniProt (Q8WY64) Pfam (PF13920) | HOMO SAPIENS (HUMAN) | INDUCIBLE DEGRADER OF THE LDL-RECEPTOR, IDOL, MYOSIN REGULATORY LIGHT CHAIN INTERACTING PROTEIN, MIR |
| 2 | B, D, F, H (B, D, F, H) | UBIQUITIN-CONJUGATING ENZYME E2 D1 | polymer | 149 | 16750.1 | 4 | UniProt (P51668) Pfam (PF00179) | HOMO SAPIENS (HUMAN) | STIMULATOR OF FE TRANSPORT, SFT, UBC4/5 HOMOLOG, UBCH5, UBIQUITIN CARRIER PROTEIN D1, UBIQUITIN-CONJUGATING ENZYME E2(17)KB 1, UBIQUITIN-CONJUGATING ENZYME E2-17 KDA 1, UBIQUITIN-PROTEIN LIGASE D1, UBE2D1 |
| 3 | I, J, O, P, Q... (A, C, E, G) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | K, L, M, N, S... (A, B, F, G, H) | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
| 5 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 406 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 369 - 445 (UniProt: Q8WY64)
B, D, F, H: 1 - 147 (UniProt: P51668)
| PDB | External Database | Details |
|---|---|---|
| Gly 367 | - | expression tag |
| Ala 368 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 102446.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1054.7 | |
| All* | Total formula weight | 103500.9 |
