2Y4I
KSR2-MEK1 heterodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | KINASE SUPPRESSOR OF RAS 2 | polymer | 319 | 36800.6 | 1 | UniProt (Q6VAB6) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | KSR2, HKSR2 |
| 2 | B (C) | DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 | polymer | 395 | 43646.2 | 1 | UniProt (P29678) Pfam (PF00069) | ORYCTOLAGUS CUNICULUS (RABBIT) | MEK1, MAP KINASE KINASE 1, MAPKK 1, ERK ACTIVATOR KINASE 1, MAPK/ERK KINASE 1, MEK 1 |
| 3 | C, E (B, C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | D, F (B, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | G (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) |
Sequence modifications
B: 634 - 950 (UniProt: Q6VAB6)
C: 1 - 393 (UniProt: P29678)
| PDB | External Database | Details |
|---|---|---|
| Gly 632 | - | expression tag |
| Pro 633 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Leu 38 | Glu 38 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80446.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1098.4 | |
| All* | Total formula weight | 81545.2 |
