Functional Information from GO Data
Chain | GOid | namespace | contents |
B | 0004672 | molecular_function | protein kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0000165 | biological_process | MAPK cascade |
C | 0004672 | molecular_function | protein kinase activity |
C | 0004674 | molecular_function | protein serine/threonine kinase activity |
C | 0004708 | molecular_function | MAP kinase kinase activity |
C | 0004713 | molecular_function | protein tyrosine kinase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0005739 | cellular_component | mitochondrion |
C | 0005769 | cellular_component | early endosome |
C | 0005770 | cellular_component | late endosome |
C | 0005813 | cellular_component | centrosome |
C | 0005816 | cellular_component | spindle pole body |
C | 0005856 | cellular_component | cytoskeleton |
C | 0005925 | cellular_component | focal adhesion |
C | 0006468 | biological_process | protein phosphorylation |
C | 0016020 | cellular_component | membrane |
C | 0016310 | biological_process | phosphorylation |
C | 0032872 | biological_process | regulation of stress-activated MAPK cascade |
C | 0090170 | biological_process | regulation of Golgi inheritance |
C | 0106310 | molecular_function | protein serine kinase activity |
C | 2000641 | biological_process | regulation of early endosome to late endosome transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE ATP B 1932 |
Chain | Residue |
B | ILE672 |
B | LYS788 |
B | LYS790 |
B | ASN791 |
B | PHE793 |
B | ASP803 |
B | GLN825 |
B | MG1933 |
B | LYS674 |
B | GLY675 |
B | ARG676 |
B | ARG692 |
B | THR739 |
B | SER740 |
B | LEU741 |
B | CYS742 |
site_id | AC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 1933 |
Chain | Residue |
B | ASN791 |
B | ASP803 |
B | ATP1932 |
site_id | AC3 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE ATP C 1382 |
Chain | Residue |
C | ALA76 |
C | GLY77 |
C | VAL82 |
C | ALA95 |
C | LYS97 |
C | MET143 |
C | GLU144 |
C | MET146 |
C | GLY149 |
C | SER150 |
C | GLN153 |
C | ASP190 |
C | LYS192 |
C | SER194 |
C | ASN195 |
C | LEU197 |
C | ASP208 |
C | MG1383 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG C 1383 |
Chain | Residue |
C | SER194 |
C | ASN195 |
C | CYS207 |
C | ASP208 |
C | ATP1382 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 1384 |
Chain | Residue |
C | ASN319 |
C | ALA347 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGNGGVVFkVshkpsglv..........MARK |
Chain | Residue | Details |
C | LEU74-LYS97 | |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKpsNILV |
Chain | Residue | Details |
C | ILE186-VAL198 | |
B | ILE782-TYR794 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
C | ASP190 | |
Chain | Residue | Details |
C | LEU74 | |
C | LYS97 | |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | SITE: Cleavage; by anthrax lethal factor => ECO:0000250 |
Chain | Residue | Details |
C | PRO8 | |
B | ASP803 | |
Chain | Residue | Details |
C | SER218 | |
C | SER222 | |
Chain | Residue | Details |
C | THR286 | |
Chain | Residue | Details |
C | THR292 | |
Chain | Residue | Details |
C | SER298 | |