2XRW
Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 8 | polymer | 371 | 42774.4 | 1 | UniProt (A1L4K2) Pfam (PF00069) UniProt (by SIFTS) (P45983) | HOMO SAPIENS (HUMAN) | JNK1, MITOGEN-ACTIVATED PROTEIN KINASE 8 ISOFORM JNK1 BETA2, MITOGEN-ACTIVATED PROTEIN KINASE 8\,ISOFORM CRA_D, CDNA FLJ77387\,HIGHLY SIMILAR TO HOMO SAPIENS MITOGEN-ACTIVATED PROTEIN KINASE 8 (MAPK8)\,TRANSCRIPT VARIANT 4\,MRNA |
| 2 | B (B) | NUCLEAR FACTOR OF ACTIVATED T-CELLS\, CYTOPLASMIC 3 | polymer | 14 | 1741.0 | 1 | UniProt (Q12968) | HOMO SAPIENS | PEPNFAT4, NF-ATC3, NFATC3, T-CELL TRANSCRIPTION FACTOR NFAT4, NF-AT4, NFATX |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 422 | Chemie (HOH) |
Sequence modifications
A: 2 - 364 (UniProt: A1L4K2)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Gly 1 | - | expression tag |
| His 365 | - | expression tag |
| His 366 | - | expression tag |
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44515.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 690.4 | |
| All* | Total formula weight | 45205.7 |
