2XRW

Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	MITOGEN-ACTIVATED PROTEIN KINASE 8	polymer	371	42774.4	1	UniProt (A1L4K2) Pfam (PF00069) UniProt (by SIFTS) (P45983) In PDB	HOMO SAPIENS (HUMAN)	JNK1, MITOGEN-ACTIVATED PROTEIN KINASE 8 ISOFORM JNK1 BETA2, MITOGEN-ACTIVATED PROTEIN KINASE 8\,ISOFORM CRA_D, CDNA FLJ77387\,HIGHLY SIMILAR TO HOMO SAPIENS MITOGEN-ACTIVATED PROTEIN KINASE 8 (MAPK8)\,TRANSCRIPT VARIANT 4\,MRNA
2	B	NUCLEAR FACTOR OF ACTIVATED T-CELLS\, CYTOPLASMIC 3	polymer	14	1741.0	1	UniProt (Q12968) In PDB	HOMO SAPIENS	PEPNFAT4, NF-ATC3, NFATC3, T-CELL TRANSCRIPTION FACTOR NFAT4, NF-AT4, NFATX
3	A	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	1	Chemie (ANP)
4	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	422	Chemie (HOH)

Sequence modifications

A: 2 - 364 (UniProt: A1L4K2)

PDB	External Database	Details
Met 0	-	expression tag
Gly 1	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44515.3
Non-Polymers*	Number of molecules	3
	Total formula weight	690.4
All*	Total formula weight	45205.7

*Water molecules are not included.