2X1X

CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (E)	VASCULAR ENDOTHELIAL GROWTH FACTOR C	polymer	110	12390.2	1	UniProt (P49767) Pfam (PF00341)	HOMO SAPIENS (HUMAN)	VEGF-C, VASCULAR ENDOTHELIAL GROWTH FACTOR-RELATED PROTEIN, VRP, FLT4 LIGAND, FLT4-L
2	B (R)	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	polymer	213	23909.3	1	UniProt (P35968) Pfam (PF21339) Pfam (PF00047)	HOMO SAPIENS (HUMAN)	VEGF RECEPTOR 2, VEGFR-2, KINASE INSERT DOMAIN RECEPTOR, PROTEIN-TYROSINE KINASE RECEPTOR FLK-1
3	C, D (A, B)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	E, F (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	G (R)	MERCURY (II) ION	non-polymer		200.6	1	Chemie (HG)
6	H (R)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	I, J (E, R)	water	water		18.0	12	Chemie (HOH)

Sequence modifications

E: 112 - 215 (UniProt: P49767)

PDB	External Database	Details
Ala 137	Cys 137	engineered mutation

E: 216 - 221 (PDB: 2X1X)
R: 120 - 326 (UniProt: P35968)
R: 327 - 332 (PDB: 2X1X)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36299.5
Branched	Number of molecules	4
	Total formula weight	2021.9
Non-Polymers*	Number of molecules	2
	Total formula weight	421.8
All*	Total formula weight	38743.1

*Water molecules are not included.