2WV5
Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | PICORNAIN 3C | polymer | 214 | 23049.7 | 4 | UniProt (P03306) Pfam (PF00548) In PDB | FOOT-AND-MOUTH DISEASE VIRUS | FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE, PROTEASE 3C, P3C, PROTEASE P20B |
2 | E, F, G, H | FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN | polymer | 11 | 1144.3 | 4 | UniProt (Q65050) UniProt (by SIFTS) (P03306) In PDB | FOOT-AND-MOUTH DISEASE VIRUS | |
3 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 0 (PDB: 2WV5)
A, B, C, D: 1 - 213 (UniProt: P03306)
E, F, G, H: 1 - 1 (PDB: 2WV5)
E, F, G, H: 2 - 11 (UniProt: Q65050)
A, B, C, D: 1 - 213 (UniProt: P03306)
PDB | External Database | Details |
---|---|---|
Ile 22 | Asn 1671 | SEE REMARK 999 |
Met 88 | Ile 1737 | SEE REMARK 999 |
Lys 95 | Cys 1744 | engineered mutation |
Leu 142 | Cys 1791 | engineered mutation |
Ala 163 | Cys 1812 | engineered mutation |
E, F, G, H: 2 - 11 (UniProt: Q65050)
PDB | External Database | Details |
---|---|---|
Glu 6 | Gln 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 96775.8 | |
All* | Total formula weight | 96775.8 |