2WV5

Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Cleavage; by picornain 3C => ECO:0000255

Chain	Residue	Details
E	GLU6
F	GLU6
G	GLU6
H	GLU6

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site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222, ECO:0000269|PubMed:15654079

Chain	Residue	Details
A	ASP84
A	ALA163
B	ASP84
B	ALA163
C	ASP84
C	ALA163
D	ASP84
D	ALA163

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site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Important for catalytic activity => ECO:0007744|PDB:2BHG

Chain	Residue	Details
A	SER182
B	SER182
C	SER182
D	SER182

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Cleavage; by picornain 3C => ECO:0000255

Chain	Residue	Details
A	GLU213
B	GLU213
C	GLU213
D	GLU213

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
A	HIS46	proton shuttle (general acid/base)
A	ASP84	electrostatic stabiliser
A	ALA163	covalent catalysis
A	SER182	electrostatic stabiliser

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site_id	MCSA2
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
B	HIS46	proton shuttle (general acid/base)
B	ASP84	electrostatic stabiliser
B	ALA163	covalent catalysis
B	SER182	electrostatic stabiliser

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site_id	MCSA3
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
C	HIS46	proton shuttle (general acid/base)
C	ASP84	electrostatic stabiliser
C	ALA163	covalent catalysis
C	SER182	electrostatic stabiliser

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site_id	MCSA4
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
D	HIS46	proton shuttle (general acid/base)
D	ASP84	electrostatic stabiliser
D	ALA163	covalent catalysis
D	SER182	electrostatic stabiliser

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