2WV5
Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For protease 3C activity; Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15654079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"For protease 3C activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01222","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15654079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"PDB","id":"2BHG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| A | SER182 | |
| A | HIS46 | |
| A | ALA163 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| B | SER182 | |
| B | HIS46 | |
| B | ALA163 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| C | SER182 | |
| C | HIS46 | |
| C | ALA163 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 2bhg |
| Chain | Residue | Details |
| D | SER182 | |
| D | HIS46 | |
| D | ALA163 |
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| A | HIS46 | proton shuttle (general acid/base) |
| A | ASP84 | electrostatic stabiliser |
| A | ALA163 | covalent catalysis |
| A | SER182 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| B | HIS46 | proton shuttle (general acid/base) |
| B | ASP84 | electrostatic stabiliser |
| B | ALA163 | covalent catalysis |
| B | SER182 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| C | HIS46 | proton shuttle (general acid/base) |
| C | ASP84 | electrostatic stabiliser |
| C | ALA163 | covalent catalysis |
| C | SER182 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 763 |
| Chain | Residue | Details |
| D | HIS46 | proton shuttle (general acid/base) |
| D | ASP84 | electrostatic stabiliser |
| D | ALA163 | covalent catalysis |
| D | SER182 | electrostatic stabiliser |
