2WV5
Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction with a GLN to Glu substitution at P1
Summary for 2WV5
Entry DOI | 10.2210/pdb2wv5/pdb |
Related | 1ZBA 1ZBE 2BHG 2J92 2WV4 |
Descriptor | PICORNAIN 3C, FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN (3 entities in total) |
Functional Keywords | 3c protease, hydrolase, viral protein, hydrolase peptide complex, hydrolase-peptide complex, hydrolase/peptide |
Biological source | FOOT-AND-MOUTH DISEASE VIRUS More |
Cellular location | Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B-1: Virion (Potential). Protein 3B-2: Virion (Potential). Protein 3B-3: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P03306 |
Total number of polymer chains | 8 |
Total formula weight | 96775.80 |
Authors | Zunszain, P.A.,Knox, S.R.,Sweeney, T.R.,Yang, J.,Roque-Rosell, N.,Belsham, G.J.,Leatherbarrow, R.J.,Curry, S. (deposition date: 2009-10-13, release date: 2009-10-27, Last modification date: 2023-12-20) |
Primary citation | Zunszain, P.A.,Knox, S.R.,Sweeney, T.R.,Yang, J.,Roque-Rosell, N.,Belsham, G.J.,Leatherbarrow, R.J.,Curry, S. Insights Into Cleavage Specificity from the Crystal Structure of Foot-and-Mouth Disease Virus 3C Protease Complexed with a Peptide Substrate. J.Mol.Biol., 395:375-, 2010 Cited by PubMed: 19883658DOI: 10.1016/J.JMB.2009.10.048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report