2WV4

Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	PICORNAIN 3C	polymer	214	23049.7	2	UniProt (P03306) Pfam (PF00548) In PDB	FOOT-AND-MOUTH DISEASE VIRUS	FOOT-AND-MOUTH DISEASE VIRUS 3C PROTEASE, PROTEASE 3C, P3C, PROTEASE P20B
2	C, D	FOOT AND MOUTH DISEASE VIRUS (SEROTYPE A) VARIANT VP1 CAPSID PROTEIN	polymer	11	1143.3	2	UniProt (Q65050) UniProt (by SIFTS) (P03306) In PDB	FOOT-AND-MOUTH DISEASE VIRUS
3		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, B: 0 - 0 (PDB: 2WV4)
A, B: 1 - 213 (UniProt: P03306)

PDB	External Database	Details
Ile 22	Asn 1671	SEE REMARK 999
Met 88	Ile 1737	SEE REMARK 999
Lys 95	Cys 1744	engineered mutation
Leu 142	Cys 1791	engineered mutation
Ala 163	Cys 1812	engineered mutation

C, D: 1 - 1 (PDB: 2WV4)
C, D: 2 - 11 (UniProt: Q65050)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	48385.9
All*	Total formula weight	48385.9

*Water molecules are not included.