2WV4

Crystal structure of foot-and-mouth disease virus 3C protease in complex with a decameric peptide corresponding to the VP1-2A cleavage junction

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Cleavage; by picornain 3C => ECO:0000255

Chain	Residue	Details
C	GLN6
D	GLN6

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222, ECO:0000269|PubMed:15654079

Chain	Residue	Details
A	ASP84
A	ALA163
B	ASP84
B	ALA163

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site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0007744|PDB:2BHG

Chain	Residue	Details
A	SER182
B	SER182

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by picornain 3C => ECO:0000255

Chain	Residue	Details
A	GLU213
B	GLU213

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 2bhg

Chain	Residue	Details
A	SER182
A	HIS46
A	ALA163

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 2bhg

Chain	Residue	Details
B	SER182
B	HIS46
B	ALA163

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site_id	MCSA1
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
A	HIS46	proton shuttle (general acid/base)
A	ASP84	electrostatic stabiliser
A	ALA163	covalent catalysis
A	SER182	electrostatic stabiliser

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site_id	MCSA2
Number of Residues
Details	M-CSA 763

Chain	Residue	Details
B	HIS46	proton shuttle (general acid/base)
B	ASP84	electrostatic stabiliser
B	ALA163	covalent catalysis
B	SER182	electrostatic stabiliser

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