2WHX
A second conformation of the NS3 protease-helicase from dengue virus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE PROTEASE/NTPASE/HELICASE NS3 | polymer | 618 | 69489.2 | 1 | UniProt (Q2YHF0) | DENGUE VIRUS 4 | THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS, NON-STRUCTURAL PROTEIN 3, SERINE PROTEASE SUBUNIT NS3, SERINE PROTEASE SUBUNIT NS3, NON-STRUCTURAL PROTEIN 3 |
| 2 | B (C) | SERINE PROTEASE SUBUNIT NS2B | polymer | 14 | 1560.7 | 1 | UniProt (Q2YHF0) | DENGUE VIRUS 4 | THE NS3 PROTEASE-HELICASE FROM DENGUE VIRUS, NON-STRUCTURAL PROTEIN 2B, FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT |
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 5 | E, F (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G (A) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 1 - 618 (UniProt: Q2YHF0)
| PDB | External Database | Details |
|---|---|---|
| Lys 143 | Arg 1617 | conflict |
| Asp 250 | Glu 1724 | conflict |
| Cys 292 | Ser 1766 | conflict |
| Ser 321 | Thr 1795 | conflict |
| Arg 381 | Lys 1855 | conflict |
| Lys 480 | Arg 1954 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71049.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 553.0 | |
| All* | Total formula weight | 71602.9 |
