2WHX

A second conformation of the NS3 protease-helicase from dengue virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 1619

Chain	Residue
A	GLY196
A	HOH2133
A	HOH2134
A	HOH2136
A	HOH2137
A	ALA197
A	GLY198
A	LYS199
A	THR200
A	LYS201
A	ASN329
A	ARG463
A	MN1620

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 1620

Chain	Residue
A	THR200
A	GLU285
A	ADP1619
A	HOH2135
A	HOH2136
A	HOH2137

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1621

Chain	Residue
A	LYS199
A	ALA316
A	GLN456
A	HOH2091

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1622

Chain	Residue
A	ILE365
A	ARG387
A	THR408

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
A	HIS51
A	ASP75
A	SER135

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU193

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG457
A	ARG460

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
A	LYS618

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