2WHH
HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POL PROTEIN | polymer | 203 | 21902.8 | 1 | UniProt (Q9QJ78) Pfam (PF00077) UniProt (by SIFTS) (P04585) | HUMAN IMMUNODEFICIENCY VIRUS 1 | HIV-1 PROTEASE |
| 2 | B, D (A) | PARA-NITROPHENYLALANINE | non-polymer | 210.2 | 2 | Chemie (PPN) | |||
| 3 | C, E (A) | GLUTAMIC ACID | non-polymer | 147.1 | 2 | Chemie (GLU) | |||
| 4 | F (A) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: Q9QJ78)
A: 1001 - 1099 (UniProt: Q9QJ78)
A: 100 - 104 (PDB: 2WHH)
| PDB | External Database | Details |
|---|---|---|
| Val 3 | Ile 9 | conflict |
| Ile 62 | Val 68 | conflict |
| Met 95 | Cys 101 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 1003 | Ile 9 | conflict |
| Ile 1062 | Val 68 | conflict |
| Ala 1095 | Cys 101 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 21902.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 714.6 | |
| All* | Total formula weight | 22617.4 |
