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2WHH

HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule

Summary for 2WHH
Entry DOI10.2210/pdb2whh/pdb
DescriptorPOL PROTEIN, PARA-NITROPHENYLALANINE, GLUTAMIC ACID, ... (4 entities in total)
Functional Keywordsprotease, hydrolase, drug design, transferase, nucleotidyltransferase, rna-directed dna polymerase, catalytic mechanism, multifunctional enzyme, transition state, aspartyl protease
Biological sourceHUMAN IMMUNODEFICIENCY VIRUS 1
Total number of polymer chains1
Total formula weight22617.39
Authors
Prashar, V.,Bihani, S.,Das, A.,Ferrer, J.L.,Hosur, M.V. (deposition date: 2009-05-05, release date: 2009-12-01, Last modification date: 2023-12-13)
Primary citationPrashar, V.,Bihani, S.,Das, A.,Ferrer, J.L.,Hosur, M.V.
Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis.
Plos One, 4:E7860-, 2009
Cited by
PubMed: 19924250
DOI: 10.1371/JOURNAL.PONE.0007860
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

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