2WHH
HIV-1 protease tethered dimer Q-product complex along with nucleophilic water molecule
Summary for 2WHH
Entry DOI | 10.2210/pdb2whh/pdb |
Descriptor | POL PROTEIN, PARA-NITROPHENYLALANINE, GLUTAMIC ACID, ... (4 entities in total) |
Functional Keywords | protease, hydrolase, drug design, transferase, nucleotidyltransferase, rna-directed dna polymerase, catalytic mechanism, multifunctional enzyme, transition state, aspartyl protease |
Biological source | HUMAN IMMUNODEFICIENCY VIRUS 1 |
Total number of polymer chains | 1 |
Total formula weight | 22617.39 |
Authors | Prashar, V.,Bihani, S.,Das, A.,Ferrer, J.L.,Hosur, M.V. (deposition date: 2009-05-05, release date: 2009-12-01, Last modification date: 2023-12-13) |
Primary citation | Prashar, V.,Bihani, S.,Das, A.,Ferrer, J.L.,Hosur, M.V. Catalytic Water Co-Existing with a Product Peptide in the Active Site of HIV-1 Protease Revealed by X- Ray Structure Analysis. Plos One, 4:E7860-, 2009 Cited by PubMed: 19924250DOI: 10.1371/JOURNAL.PONE.0007860 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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