Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PPN A 2201 |
| Chain | Residue |
| A | ARG8 |
| A | HOH2174 |
| A | HOH2175 |
| A | HOH2183 |
| A | GLU2202 |
| A | PPN2301 |
| A | LEU23 |
| A | ASP25 |
| A | PRO81 |
| A | VAL82 |
| A | GLY1027 |
| A | HOH2170 |
| A | HOH2172 |
| A | HOH2173 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GLU A 2202 |
| Chain | Residue |
| A | GLY1027 |
| A | ASP1029 |
| A | ASP1030 |
| A | ILE1047 |
| A | GLY1048 |
| A | HOH2174 |
| A | HOH2184 |
| A | HOH2185 |
| A | HOH2186 |
| A | HOH2187 |
| A | PPN2201 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PPN A 2301 |
| Chain | Residue |
| A | GLY27 |
| A | ARG1008 |
| A | LEU1023 |
| A | ASP1025 |
| A | PRO1081 |
| A | VAL1082 |
| A | ILE1084 |
| A | HOH2170 |
| A | HOH2175 |
| A | HOH2180 |
| A | HOH2181 |
| A | HOH2182 |
| A | HOH2183 |
| A | PPN2201 |
| A | GLU2302 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GLU A 2302 |
| Chain | Residue |
| A | GLY27 |
| A | ASP29 |
| A | ASP30 |
| A | GLY48 |
| A | HOH2176 |
| A | HOH2177 |
| A | HOH2178 |
| A | HOH2179 |
| A | HOH2181 |
| A | HOH2182 |
| A | PPN2301 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL |
| Chain | Residue | Details |
| A | ALA22-LEU33 | |
| A | ALA1022-LEU1033 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"PubMed","id":"2162350","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33542150","evidenceCode":"ECO:0000305"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 175 |
| Chain | Residue | Details |
| A | ASP25 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | THR26 | electrostatic stabiliser, transition state stabiliser |
| A | GLY27 | electrostatic stabiliser, hydrogen bond donor |
