2WD0
CRYSTAL STRUCTURE OF NONSYNDROMIC DEAFNESS (DFNB12) ASSOCIATED MUTANT D124G OF MOUSE CADHERIN-23 EC1-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | CADHERIN-23 | polymer | 214 | 23798.4 | 2 | UniProt (Q99PF4) Pfam (PF00028) | MUS MUSCULUS (HOUSE MOUSE) | OTOCADHERIN |
| 2 | C, D, E, I, J... (A, C) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
| 3 | F, L (A, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | G, H, M (A, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | N, O (A, C) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 206 (UniProt: Q99PF4)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | expression tag |
| Gly 102 | Asp 124 | engineered mutation |
| Leu 207 | - | expression tag |
| Glu 208 | - | expression tag |
| His 209 | - | expression tag |
| His 210 | - | expression tag |
| His 211 | - | expression tag |
| His 212 | - | expression tag |
| His 213 | - | expression tag |
| His 214 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47596.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 392.8 | |
| All* | Total formula weight | 47989.6 |
