2WBY
Crystal structure of human insulin-degrading enzyme in complex with insulin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | INSULIN-DEGRADING ENZYME | polymer | 990 | 114560.6 | 2 | UniProt (P14735) Pfam (PF00675) Pfam (PF05193) Pfam (PF16187) In PDB | HOMO SAPIENS (HUMAN) | INSULIN PROTEASE, INSULYSIN, INSULINASE |
2 | C, E | INSULIN A CHAIN | polymer | 20 | 2269.6 | 2 | UniProt (P01308) In PDB | HOMO SAPIENS | |
3 | D, F | INSULIN B CHAIN | polymer | 19 | 2147.5 | 2 | UniProt (P01308) In PDB | HOMO SAPIENS | |
4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
5 | water | water | 18.0 | 722 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 41 (PDB: 2WBY)
A, B: 42 - 1019 (UniProt: P14735)
A, B: 42 - 1019 (UniProt: P14735)
PDB | External Database | Details |
---|---|---|
Leu 110 | Cys 110 | engineered mutation |
Gln 111 | Glu 111 | engineered mutation |
Ser 171 | Cys 171 | engineered mutation |
Ala 178 | Cys 178 | engineered mutation |
Val 257 | Cys 257 | engineered mutation |
Leu 414 | Cys 414 | engineered mutation |
Asn 573 | Cys 573 | engineered mutation |
Ser 590 | Cys 590 | engineered mutation |
Ser 789 | Cys 789 | engineered mutation |
Ala 812 | Cys 812 | engineered mutation |
Ala 819 | Cys 819 | engineered mutation |
Ser 904 | Cys 904 | engineered mutation |
Asn 966 | Cys 966 | engineered mutation |
Ala 974 | Cys 974 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 237955.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 130.8 | |
All* | Total formula weight | 238086.2 |