2WB5
GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | O-GLCNACASE NAGJ | polymer | 594 | 66689.7 | 2 | UniProt (Q0TR53) Pfam (PF02838) Pfam (PF07555) Pfam (PF21774) | CLOSTRIDIUM PERFRINGENS | BETA-HEXOSAMINIDASE, GH84, HEXOSAMINIDASE B, N-ACETYL-BETA-GLUCOSAMINIDASE, BETA-N-ACETYLHEXOSAMINIDASE |
| 2 | C, D, G, H, I (A, B) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 3 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F, J (A, B) | (5R,6R,7R,8S)-6,7-dihydroxy-5-(hydroxymethyl)-2-(2-phenylethyl)-8-(propanoylamino)-5,6,7,8-tetrahydro-1H-imidazo[1,2-a]pyridin-4-ium | non-polymer | 360.4 | 2 | Chemie (VGB) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 641 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 624 (UniProt: Q0TR53)
| PDB | External Database | Details |
|---|---|---|
| Asp 388 | Asn 388 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 133379.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 921.1 | |
| All* | Total formula weight | 134300.5 |
