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2WB5

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 1625
ChainResidue
AGLU557
AALA597
ASER600
AALA602

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 1626
ChainResidue
APHE265

site_idAC3
Number of Residues1
DetailsBINDING SITE FOR RESIDUE NA A 1627
ChainResidue
AASN390

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE VGB A 1628
ChainResidue
AASP297
AASP298
ATYR335
ATHR366
AVAL370
ATRP394
AASN396
AASP401
ATYR402
AASN429
BASP620
AGLY187
APHE188
ALYS218

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1625
ChainResidue
BTYR456

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1626
ChainResidue
BLYS593

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1627
ChainResidue
BPHE265

site_idAC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE VGB B 1628
ChainResidue
ALEU621
BGLY187
BPHE188
BTYR189
BLYS218
BASP297
BASP298
BTYR335
BTHR366
BVAL370
BTRP394
BASN396
BASP401
BASN429

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU01353, ECO:0000269|PubMed:16541109
ChainResidueDetails
AASP298
BASP298

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:16541109
ChainResidueDetails
AGLY187
BASP297
BTYR335
BTRP394
BASP401
BASN429
ALYS218
AASP297
ATYR335
ATRP394
AASP401
AASN429
BGLY187
BLYS218

226707

PDB entries from 2024-10-30

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