2W98
CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND PHENYLBUTAZONE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | PROSTAGLANDIN REDUCTASE 2 | polymer | 357 | 39331.7 | 2 | UniProt (Q8N8N7) Pfam (PF16884) Pfam (PF00107) | HOMO SAPIENS (HUMAN) | PRG-2,15-OXOPROSTAGLANDIN 13-REDUCTASE, ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 1, ZINC-BINDING ALCOHOL DEHYDROGENASE 1 |
| 2 | C, J (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, E, F, K, L... (A, B) | 4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE | non-polymer | 308.4 | 7 | Chemie (P1Z) | |||
| 4 | G, H, I, O, P (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 5 | Q (B) | (2S)-2-hydroxybutanedioic acid | non-polymer | 134.1 | 1 | Chemie (LMR) | |||
| 6 | R (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | S (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | T, U (A, B) | water | water | 18.0 | 493 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 349 (UniProt: Q8N8N7)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
| Ala 350 | - | expression tag |
| Glu 351 | - | expression tag |
| Asn 352 | - | expression tag |
| Leu 353 | - | expression tag |
| Tyr 354 | - | expression tag |
| Phe 355 | - | expression tag |
| Gln 356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78663.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4312.8 | |
| All* | Total formula weight | 82976.2 |
