2W83
Crystal structure of the ARF6 GTPase in complex with a specific effector, JIP4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, E (A, B, E) | ADP-RIBOSYLATION FACTOR 6 | polymer | 165 | 18990.8 | 3 | UniProt (P62330) Pfam (PF00025) | HOMO SAPIENS (HUMAN) | ARF6 |
| 2 | C, D (C, D) | C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4 | polymer | 77 | 8878.2 | 2 | UniProt (O60271) Pfam (PF16471) | HOMO SAPIENS (HUMAN) | JIP4, JNK-INTERACTING PROTEIN 4, JIP-4, JLP, HLC-6, PHET, CT89, JNK-ASSOCIATED LEUCINE-ZIPPER PROTEIN, SPERM-ASSOCIATED ANTIGEN 9, MITOGEN-ACTIVATED PROTEIN KINASE 8-INTERACTING PROTEIN 4, HUMAN LUNG CANCER ONCOGENE 6 PROTEIN, PROLIFERATION-INDUCING PROTEIN 6, SPERM-SPECIFIC PROTEIN, SPERM SURFACE PROTEIN, PROTEIN HIGHLY EXPRESSED IN TESTIS, SUNDAY DRIVER 1, CANCER/TESTIS ANTIGEN 89 |
| 3 | F, J, N (A, B, E) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 4 | G, K, O (A, B, E) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 5 | H, L, M, P, Q... (A, C, E) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 6 | Chemie (DIO) | |||
| 6 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 7 | S, T, U, V, W (A, B, C, D, E) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A, B, E: 11 - 12 (PDB: 2W83)
A, B, E: 13 - 175 (UniProt: P62330)
C, D: 386 - 391 (PDB: 2W83)
C, D: 392 - 462 (UniProt: O60271)
A, B, E: 13 - 175 (UniProt: P62330)
| PDB | External Database | Details |
|---|---|---|
| Leu 67 | Gln 67 | engineered mutation |
C, D: 392 - 462 (UniProt: O60271)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 74728.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2263.2 | |
| All* | Total formula weight | 76992.0 |
