2W2X

Complex of Rac2 and PLCg2 spPH Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2	polymer	185	20310.3	2	UniProt (P15153) Pfam (PF00071)	HOMO SAPIENS (HUMAN)	P21-RAC2, SMALL G PROTEIN, GX, RAC2
2	C (C)	1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2	polymer	124	14230.8	1	UniProt (P16885)	HOMO SAPIENS (HUMAN)	PHOSPHOINOSITIDE PHOSPHOLIPASE C, PHOSPHOLIPASE C-GAMMA-2, PLCG2
3	D (D)	1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2	polymer	124	14202.8	1	UniProt (P16885)	HOMO SAPIENS (HUMAN)	PHOSPHOINOSITIDE PHOSPHOLIPASE C, PHOSPHOLIPASE C-GAMMA-2, PLCG2
4	E, G (A, B)	5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE	non-polymer		539.2	2	Chemie (GSP)
5	F, H (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	I, J, K, L (A, B, C, D)	water	water		18.0	37	Chemie (HOH)

Sequence modifications

A, B: -5 - 1 (PDB: 2W2X)
A, B: 2 - 179 (UniProt: P15153)

PDB	External Database	Details
Val 12	Gly 12	engineered mutation

C: -5 - 1 (PDB: 2W2X)
C: 2 - 45 (UniProt: P16885)

PDB	External Database	Details
Phe 26	Tyr 495	conflict

C: 46 - 118 (UniProt: P16885)

PDB	External Database	Details
Asp 88	Tyr 883	conflict

D: -5 - 1 (PDB: 2W2X)
D: 46 - 118 (UniProt: P16885)

D: 2 - 45 (UniProt: P16885)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.