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2W2X

Complex of Rac2 and PLCg2 spPH Domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005635cellular_componentnuclear envelope
A0005737cellular_componentcytoplasm
A0005741cellular_componentmitochondrial outer membrane
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006935biological_processchemotaxis
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0008283biological_processcell population proliferation
A0008360biological_processregulation of cell shape
A0010310biological_processregulation of hydrogen peroxide metabolic process
A0010592biological_processpositive regulation of lamellipodium assembly
A0010810biological_processregulation of cell-substrate adhesion
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019887molecular_functionprotein kinase regulator activity
A0019901molecular_functionprotein kinase binding
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030036biological_processactin cytoskeleton organization
A0030670cellular_componentphagocytic vesicle membrane
A0030865biological_processcortical cytoskeleton organization
A0031410cellular_componentcytoplasmic vesicle
A0032956biological_processregulation of actin cytoskeleton organization
A0042129biological_processregulation of T cell proliferation
A0042554biological_processsuperoxide anion generation
A0042995cellular_componentcell projection
A0043020cellular_componentNADPH oxidase complex
A0043131biological_processerythrocyte enucleation
A0043304biological_processregulation of mast cell degranulation
A0045453biological_processbone resorption
A0045730biological_processrespiratory burst
A0060263biological_processregulation of respiratory burst
A0060753biological_processregulation of mast cell chemotaxis
A0070062cellular_componentextracellular exosome
A0070662biological_processmast cell proliferation
A0070668biological_processpositive regulation of mast cell proliferation
A0071593biological_processlymphocyte aggregation
A0090023biological_processpositive regulation of neutrophil chemotaxis
A1902622biological_processregulation of neutrophil migration
A1903955biological_processpositive regulation of protein targeting to mitochondrion
B0000166molecular_functionnucleotide binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005741cellular_componentmitochondrial outer membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006935biological_processchemotaxis
B0007015biological_processactin filament organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0008283biological_processcell population proliferation
B0008360biological_processregulation of cell shape
B0010310biological_processregulation of hydrogen peroxide metabolic process
B0010592biological_processpositive regulation of lamellipodium assembly
B0010810biological_processregulation of cell-substrate adhesion
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0019887molecular_functionprotein kinase regulator activity
B0019901molecular_functionprotein kinase binding
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030036biological_processactin cytoskeleton organization
B0030670cellular_componentphagocytic vesicle membrane
B0030865biological_processcortical cytoskeleton organization
B0031410cellular_componentcytoplasmic vesicle
B0032956biological_processregulation of actin cytoskeleton organization
B0042129biological_processregulation of T cell proliferation
B0042554biological_processsuperoxide anion generation
B0042995cellular_componentcell projection
B0043020cellular_componentNADPH oxidase complex
B0043131biological_processerythrocyte enucleation
B0043304biological_processregulation of mast cell degranulation
B0045453biological_processbone resorption
B0045730biological_processrespiratory burst
B0060263biological_processregulation of respiratory burst
B0060753biological_processregulation of mast cell chemotaxis
B0070062cellular_componentextracellular exosome
B0070662biological_processmast cell proliferation
B0070668biological_processpositive regulation of mast cell proliferation
B0071593biological_processlymphocyte aggregation
B0090023biological_processpositive regulation of neutrophil chemotaxis
B1902622biological_processregulation of neutrophil migration
B1903955biological_processpositive regulation of protein targeting to mitochondrion
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GSP A 1178
ChainResidue
AASP11
APRO34
ATHR35
AGLY60
ALYS116
AASP118
ALEU119
AALA159
ALEU160
AMG1179
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
APHE28
ATYR32

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE GSP B 1178
ChainResidue
BASP11
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BTYR32
BTHR35
BGLY60
BASP118
BLEU119
BSER158
BALA159
BLEU160
BMG1179

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 1179
ChainResidue
ATHR17
ATHR35
AASP57
AGSP1178

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1179
ChainResidue
BTHR17
BTHR35
BASP57
BGSP1178

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsMotif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosylasparagine; by botulinum toxin","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN61

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA13

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA13

239149

PDB entries from 2025-07-23

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