2VOF

Structure of mouse A1 bound to the Puma BH3-domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	BCL-2-RELATED PROTEIN A1	polymer	157	18110.0	2	UniProt (Q07440) Pfam (PF00452)	MUS MUSCULUS (MOUSE)	PROTEIN BFL-1, HEMOPOIETIC-SPECIFIC EARLY RESPONSE PROTEIN, A1-A
2	B, D (B, D)	BCL-2-BINDING COMPONENT 3	polymer	26	3193.5	2	UniProt (Q99ML1)	MUS MUSCULUS (MOUSE)	P53 UP-REGULATED MODULATOR OF APOPTOSIS
3	E, F (A, C)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H, I, J (A, B, C, D)	water	water		18.0	176	Chemie (HOH)

Sequence modifications

A, C: -4 - 0 (PDB: 2VOF)
A, C: 1 - 152 (UniProt: Q07440)

PDB	External Database	Details
Lys 104	Pro 104	engineered mutation
Ser 113	Cys 113	engineered mutation

B, D: 130 - 155 (UniProt: Q99ML1)

PDB	External Database	Details
Ile 144	Met 144	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42606.9
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	42677.8

*Water molecules are not included.