2VOF

Structure of mouse A1 bound to the Puma BH3-domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
A	0043066	biological_process	negative regulation of apoptotic process
B	0005739	cellular_component	mitochondrion
B	0043065	biological_process	positive regulation of apoptotic process
B	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
B	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0042981	biological_process	regulation of apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
D	0005739	cellular_component	mitochondrion
D	0043065	biological_process	positive regulation of apoptotic process
D	0090200	biological_process	positive regulation of release of cytochrome c from mitochondria
D	0097193	biological_process	intrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A1151

Chain	Residue
A	HIS10
C	MSE7
C	HIS10

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C1150

Chain	Residue
C	ASN85
C	TRP86
C	HOH2076
D	ASN149

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. EFeDGiiNWGRIVTIFaFGG

Chain	Residue	Details
A	GLU78-GLY97

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIrqnGGWEdGF

Chain	Residue	Details
A	TRP133-PHE144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"BH1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Motif: {"description":"BH3"}

Chain

Residue

Details

---