2VIF
Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SUPPRESSOR OF CYTOKINE SIGNALLING 6 | polymer | 141 | 15918.7 | 1 | UniProt (O14544) Pfam (PF00017) | HOMO SAPIENS (HUMAN) | SOCS-6, SUPPRESSOR OF CYTOKINE SIGNALING 4, SOCS-4, CYTOKINE-INDUCIBLE SH2 PROTEIN 4, CIS-4 |
| 2 | B (P) | MAST/STEM CELL GROWTH FACTOR RECEPTOR | polymer | 11 | 1349.3 | 1 | UniProt (P10721) | HOMO SAPIENS (HUMAN) | SCFR, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE KIT, C-KIT, CD117 ANTIGEN |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D, E (A, P) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 361 - 499 (UniProt: O14544)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Asp 368 | Val 368 | conflict |
| Gly 463 | Arg 463 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 17268.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 62.1 | |
| All* | Total formula weight | 17330.1 |
