2VIF

Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005942	cellular_component	phosphatidylinositol 3-kinase complex
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046935	molecular_function	1-phosphatidylinositol-3-kinase regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1497

Chain	Residue
A	VAL455
A	SER473
A	ARG474
A	SER480
A	ALA481
A	TYR483
A	HOH2118

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"12824176","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19265199","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21030588","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9038210","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"12824176","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9038210","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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