2VDN

Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide

Replaces:  1TY6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	INTEGRIN ALPHA-IIB	polymer	452	49030.4	1	UniProt (P08514) Pfam (PF01839) In PDB	HOMO SAPIENS (HUMAN)	PLATELET MEMBRANE GLYCOPROTEIN IIB, GPALPHA IIB, GPIIB, INTEGRIN ALPHA-IIB HEAVY CHAIN
2	B	INTEGRIN BETA-3	polymer	461	50969.7	1	UniProt (P05106) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) In PDB	HOMO SAPIENS (HUMAN)	PLATELET MEMBRANE GLYCOPROTEIN IIIA, GPIIIA, CD61 ANTIGEN
3	C	EPTIFIBATIDE	polymer	8	833.0	1		SYNTHETIC CONSTRUCT	MPT HRG GLY ASP TRP PRO CYS NH2
4	H	MONOCLONAL ANTIBODY 10E5 HEAVY CHAIN	polymer	221	23766.5	1		MUS MUSCULUS (HOUSE MOUSE)
5	L	MONOCLONAL ANTIBODY 10E5 LIGHT CHAIN	polymer	214	23332.7	1		MUS MUSCULUS (HOUSE MOUSE)
6	D	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G21381MC)
7	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G09609EN)
8	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
9	A, B	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
10	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
11	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
12		water	water		18.0	364	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	147932.2
Branched	Number of molecules	2
	Total formula weight	2145.9
Non-Polymers*	Number of molecules	12
	Total formula weight	1112.6
All*	Total formula weight	151190.7

*Water molecules are not included.