2VDN
Re-refinement of Integrin AlphaIIbBeta3 Headpiece Bound to Antagonist Eptifibatide
Replaces: 1TY6Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| A | ASP434 | |
| B | SER121 | |
| B | GLU220 | |
| A | ARG303 | |
| A | ASP305 | |
| A | ASP365 | |
| A | ASP367 | |
| A | ASP369 | |
| A | TYR371 | |
| A | ASP373 | |
| A | ASP426 | |
| A | ASP428 | |
| A | ASN430 | |
| A | TYR432 | |
| A | GLU252 | |
| A | ASP297 | |
| A | ASN299 | |
| A | ASP301 | |
| A | ASP247 | |
| A | THR250 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | SER123 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASP127 | |
| B | ASP126 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU |
| Chain | Residue | Details |
| B | ASP158 | |
| B | ASN215 | |
| B | ASP217 | |
| B | PRO219 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M |
| Chain | Residue | Details |
| B | ASP251 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | MET335 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN99 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN320 | |
| B | ASN371 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE |
| Chain | Residue | Details |
| B | ASN452 |
