2RH1
High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | beta-2-adrenergic receptor/T4-lysozyme chimera | polymer | 500 | 56601.4 | 1 | UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (human ) | Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor / Lysis protein, Muramidase, Endolysin |
2 | B | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
3 | A | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
4 | A | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol | non-polymer | 298.4 | 1 | Chemie (CAU) | |||
5 | A | 1,4-BUTANEDIOL | non-polymer | 90.1 | 2 | Chemie (BU1) | |||
6 | A | ACETAMIDE | non-polymer | 59.1 | 1 | Chemie (ACM) | |||
7 | A | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) | |||
8 | A | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
9 | A | DODECAETHYLENE GLYCOL | non-polymer | 546.6 | 1 | Chemie (12P) | |||
10 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 1 - 230 (UniProt: P07550)
A: 1002 - 1161 (UniProt: P00720)
A: 263 - 365 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
Glu 187 | Asn 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 1054 | Cys 54 | engineered mutation |
Ala 1097 | Cys 97 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 56601.4 | |
Branched | Number of molecules | 1 |
Total formula weight | 342.3 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 3077.1 | |
All* | Total formula weight | 60020.8 |