2RH1

High resolution crystal structure of human B2-adrenergic G protein-coupled receptor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	beta-2-adrenergic receptor/T4-lysozyme chimera	polymer	500	56601.4	1	UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959)	Homo sapiens (human )	Beta-2 adrenergic receptor, Beta-2 adrenoceptor, Beta-2 adrenoreceptor / Lysis protein, Muramidase, Endolysin
2	B (B)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
3	C, D, E, F, G... (A)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
4	I (A)	(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol	non-polymer		298.4	1	Chemie (CAU)
5	J, K (A)	1,4-BUTANEDIOL	non-polymer		90.1	2	Chemie (BU1)
6	L (A)	ACETAMIDE	non-polymer		59.1	1	Chemie (ACM)
7	M, N, O (A)	CHOLESTEROL	non-polymer		386.7	3	Chemie (CLR)
8	P (A)	PALMITIC ACID	non-polymer		256.4	1	Chemie (PLM)
9	Q (A)	DODECAETHYLENE GLYCOL	non-polymer		546.6	1	Chemie (12P)
10	R (A)	water	water		18.0	48	Chemie (HOH)

Sequence modifications

A: 1 - 230 (UniProt: P07550)

PDB	External Database	Details
Asp -6	-	expression tag
Tyr -5	-	expression tag
Lys -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Ala 0	-	expression tag
Glu 187	Asn 187	engineered mutation

A: 1002 - 1161 (UniProt: P00720)

PDB	External Database	Details
Thr 1054	Cys 54	engineered mutation
Ala 1097	Cys 97	engineered mutation

A: 263 - 365 (UniProt: P07550)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56601.4
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	15
	Total formula weight	3077.1
All*	Total formula weight	60020.8

*Water molecules are not included.