2RD7

Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Complement component C8 alpha chain	polymer	367	41633.8	1	UniProt (P07357) Pfam (PF01823)	Homo sapiens (human)	Complement component 8 subunit alpha
2	B (C)	Complement component C8 gamma chain	polymer	184	20612.4	1	UniProt (P07360) Pfam (PF00061)	Homo sapiens (human)	Complement component 8 subunit gamma
3	C (C)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	D, E (A, C)	water	water		18.0	166	Chemie (HOH)

Sequence modifications

A: 103 - 462 (UniProt: P07357)

PDB	External Database	Details
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
Met 102	-	expression tag

C: 1 - 182 (UniProt: P07360)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62246.1
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	62281.6

*Water molecules are not included.