Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

2RD7

Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins

Functional Information from GO Data
ChainGOidnamespacecontents
A0005579cellular_componentmembrane attack complex
A0006955biological_processimmune response
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005579cellular_componentmembrane attack complex
C0005886cellular_componentplasma membrane
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0006958biological_processcomplement activation, classical pathway
C0019841molecular_functionretinol binding
C0022829molecular_functionwide pore channel activity
C0031640biological_processkilling of cells of another organism
C0044218cellular_componentother organism cell membrane
C0045087biological_processinnate immune response
C0050778biological_processpositive regulation of immune response
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0072562cellular_componentblood microparticle
C0160257biological_processcomplement activation, GZMK pathway
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL C 183
ChainResidue
AHIS310
CGLY166

Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV
ChainResidueDetails
CASN21-VAL34

site_idPS00279
Number of Residues12
DetailsMACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY
ChainResidueDetails
ATYR300-TYR311

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsTransmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

PDB statisticsPDBj update infoContact PDBjnumon