2QPU
Sugar tongs mutant S378P in complex with acarbose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Alpha-amylase type A isozyme | polymer | 405 | 44650.1 | 3 | UniProt (P00693) Pfam (PF00128) Pfam (PF07821) In PDB | Hordeum vulgare (Barley) | 1,4-alpha-D- glucan glucanohydrolase, AMY1, Low pI alpha-amylase |
| 2 | D | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose | branched | 645.6 | 1 | In PDB BIRD (PRD_900022) GlyTouCan (G08743RW) | beta-acarbose | ||
| 3 | A, B, C | CALCIUM ION | non-polymer | 40.1 | 12 | Chemie (CA) | |||
| 4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | A, B, C | 1,5-anhydro-4-O-(4,6-dideoxy-4-{[(1S,2S,3S,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-methylcyclohexyl]amino}-alpha-D-glucopyranosyl)-D-glucitol | non-polymer | 469.5 | 4 | Chemie (QPU) | |||
| 6 | C | beta-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (BGC) | |||
| 7 | water | water | 18.0 | 1726 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 405 (UniProt: P00693)
| PDB | External Database | Details |
|---|---|---|
| Val 284 | Ala 308 | engineered mutation |
| Pro 378 | Ser 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 133950.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 645.6 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2663.2 | |
| All* | Total formula weight | 137259.0 |
