2QK4
Human glycinamide ribonucleotide synthetase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Trifunctional purine biosynthetic protein adenosine-3 | polymer | 452 | 48276.3 | 2 | UniProt (P22102) Pfam (PF02844) Pfam (PF01071) Pfam (PF02843) | Homo sapiens (human) | [Includes: Phosphoribosylamine-glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)] |
| 2 | C, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, I (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, J (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, G, K, L (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 6 | M, N (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 430 (UniProt: P22102)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | cloning artifact |
| His -20 | - | cloning artifact |
| His -19 | - | cloning artifact |
| His -18 | - | cloning artifact |
| His -17 | - | cloning artifact |
| His -16 | - | cloning artifact |
| His -15 | - | cloning artifact |
| Ser -14 | - | cloning artifact |
| Ser -13 | - | cloning artifact |
| Gly -12 | - | cloning artifact |
| Val -11 | - | cloning artifact |
| Asp -10 | - | cloning artifact |
| Leu -9 | - | cloning artifact |
| Gly -8 | - | cloning artifact |
| Thr -7 | - | cloning artifact |
| Glu -6 | - | cloning artifact |
| Asn -5 | - | cloning artifact |
| Leu -4 | - | cloning artifact |
| Tyr -3 | - | cloning artifact |
| Phe -2 | - | cloning artifact |
| Gln -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| Ile 421 | Val 421 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96552.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1645.8 | |
| All* | Total formula weight | 98198.4 |
