2Q7D

Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Inositol-tetrakisphosphate 1-kinase	polymer	346	39031.3	2	UniProt (Q13572) Pfam (PF17927) Pfam (PF05770)	Homo sapiens (human)	Inositol- triphosphate 5/6-kinase, Inositol 1,3,4-trisphosphate 5/6-kinase, Ins1,3,4, P3, 5/6-kinase
2	C, D, M, N (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
3	E, F, G, H, I... (A, B)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
4	L, T (A, B)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
5	U, V (A, B)	water	water		18.0	709	Chemie (HOH)

Sequence modifications

A, B: 1 - 335 (UniProt: Q13572)

PDB	External Database	Details
Gly -10	-	expression tag
Ser -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Ile -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78062.7
Non-Polymers*	Number of molecules	18
	Total formula weight	2384.9
All*	Total formula weight	80447.6

*Water molecules are not included.