2Q7D
Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0005524 | molecular_function | ATP binding |
A | 0032957 | biological_process | inositol trisphosphate metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0047325 | molecular_function | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity |
A | 0052725 | molecular_function | inositol-1,3,4-trisphosphate 6-kinase activity |
A | 0052726 | molecular_function | inositol-1,3,4-trisphosphate 5-kinase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0005524 | molecular_function | ATP binding |
B | 0032957 | biological_process | inositol trisphosphate metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0047325 | molecular_function | inositol-3,4,5,6-tetrakisphosphate 1-kinase activity |
B | 0052725 | molecular_function | inositol-1,3,4-trisphosphate 6-kinase activity |
B | 0052726 | molecular_function | inositol-1,3,4-trisphosphate 5-kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 901 |
Chain | Residue |
A | ASP295 |
A | ASN297 |
A | ANP917 |
A | HOH1007 |
A | HOH1026 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 902 |
Chain | Residue |
A | ASP281 |
A | ASP295 |
A | ANP917 |
A | HOH988 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN B 903 |
Chain | Residue |
B | ASP281 |
B | ASP295 |
B | ANP918 |
B | HOH997 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 904 |
Chain | Residue |
B | ASP295 |
B | ASN297 |
B | ANP918 |
B | HOH1023 |
B | HOH1136 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 905 |
Chain | Residue |
A | ARG263 |
A | ARG267 |
A | HOH1025 |
B | ARG263 |
B | ARG267 |
B | HOH1000 |
B | HOH1084 |
B | HOH1206 |
site_id | AC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 906 |
Chain | Residue |
B | SER258 |
B | ASP259 |
B | GLU260 |
B | HOH949 |
B | HOH1045 |
B | HOH1050 |
B | HOH1193 |
B | HOH1207 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 907 |
Chain | Residue |
A | GLY163 |
A | THR164 |
A | ASN165 |
A | SER166 |
A | HIS167 |
A | GLU168 |
A | ASN231 |
A | HIS233 |
A | HOH1177 |
A | HOH1272 |
site_id | AC8 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE SO4 A 908 |
Chain | Residue |
A | LYS199 |
A | PHE201 |
A | ARG212 |
A | LYS237 |
A | PRO300 |
A | GLY301 |
A | TYR302 |
A | GLU303 |
A | HOH962 |
A | HOH1022 |
A | HOH1179 |
A | HOH1273 |
site_id | AC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 B 909 |
Chain | Residue |
B | LYS18 |
B | LYS59 |
B | HIS162 |
B | HOH1060 |
B | HOH1137 |
B | HOH1167 |
site_id | BC1 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE SO4 B 910 |
Chain | Residue |
B | LYS199 |
B | PHE201 |
B | ARG212 |
B | PRO300 |
B | GLY301 |
B | TYR302 |
B | GLU303 |
B | HOH985 |
B | HOH1018 |
B | HOH1175 |
B | HOH1184 |
site_id | BC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 911 |
Chain | Residue |
A | THR158 |
A | ARG159 |
A | VAL160 |
A | PRO184 |
A | HOH1180 |
A | HOH1197 |
A | HOH1280 |
site_id | BC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 912 |
Chain | Residue |
A | LYS216 |
A | PHE218 |
A | ARG225 |
A | HOH1212 |
B | LYS249 |
B | ILE250 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 913 |
Chain | Residue |
B | HIS-4 |
B | HIS-5 |
B | HIS-3 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 914 |
Chain | Residue |
A | HIS-2 |
A | HIS-3 |
A | HIS-1 |
A | HOH1089 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 915 |
Chain | Residue |
A | HIS-5 |
A | HIS-4 |
A | ILE-6 |
A | LYS-7 |
A | HOH1287 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 916 |
Chain | Residue |
A | ASP259 |
A | GLU260 |
A | HOH996 |
A | HOH1091 |
A | HOH1092 |
A | SER258 |
site_id | BC8 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE ANP A 917 |
Chain | Residue |
A | ARG106 |
A | LYS157 |
A | HIS167 |
A | MET169 |
A | GLN188 |
A | ASN189 |
A | PHE190 |
A | ILE191 |
A | HIS193 |
A | LEU197 |
A | LYS199 |
A | SER214 |
A | LEU215 |
A | SER232 |
A | SER236 |
A | ASP281 |
A | ILE294 |
A | ASP295 |
A | ASN297 |
A | MN901 |
A | MN902 |
A | HOH924 |
A | HOH986 |
A | HOH988 |
A | HOH992 |
A | HOH995 |
A | HOH1007 |
A | HOH1022 |
A | HOH1026 |
A | HOH1058 |
A | HOH1270 |
site_id | BC9 |
Number of Residues | 31 |
Details | BINDING SITE FOR RESIDUE ANP B 918 |
Chain | Residue |
B | ARG106 |
B | ILE155 |
B | LYS157 |
B | HIS167 |
B | MET169 |
B | GLN188 |
B | ASN189 |
B | PHE190 |
B | ILE191 |
B | HIS193 |
B | LEU197 |
B | LYS199 |
B | SER214 |
B | LEU215 |
B | SER232 |
B | HIS233 |
B | SER236 |
B | ASP281 |
B | ILE294 |
B | ASP295 |
B | ASN297 |
B | MN903 |
B | MN904 |
B | HOH938 |
B | HOH997 |
B | HOH1023 |
B | HOH1042 |
B | HOH1136 |
B | HOH1169 |
B | HOH1175 |
B | HOH1208 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LYS18 | |
A | HIS167 | |
A | LYS199 | |
B | LYS18 | |
B | HIS167 | |
B | LYS199 |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG106 | |
B | ARG106 | |
B | LYS157 | |
B | GLN188 | |
B | SER214 | |
B | SER232 | |
B | SER236 | |
B | ASP281 | |
B | ASP295 | |
B | ASN297 | |
A | LYS157 | |
A | GLN188 | |
A | SER214 | |
A | SER232 | |
A | SER236 | |
A | ASP281 | |
A | ASP295 | |
A | ASN297 |