2PW8
Crystal structure of sulfo-hirudin complexed to thrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin light chain | polymer | 27 | 3188.6 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (H) | Thrombin heavy chain | polymer | 258 | 29651.1 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (I) | Hirudin variant-1 | polymer | 65 | 7069.6 | 1 | UniProt (P01050) Pfam (PF00713) | Hirudo medicinalis (medicinal leech) | Lepirudin |
| 4 | D (L) | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
| 5 | E (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F, G, H (L, H, I) | water | water | 18.0 | 221 | Chemie (HOH) |
Sequence modifications
I: 3 - 65 (UniProt: P01050)
| PDB | External Database | Details |
|---|---|---|
| Leu 1 | - | expression tag |
| Thr 2 | - | expression tag |
| Tys 63 | Tyr 63 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 39909.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 81.7 | |
| All* | Total formula weight | 39991.0 |
