2PW8

Crystal structure of sulfo-hirudin complexed to thrombin

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005509	molecular_function	calcium ion binding
H	0006508	biological_process	proteolysis
H	0007596	biological_process	blood coagulation
I	0004857	molecular_function	enzyme inhibitor activity
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	1902572	biological_process	negative regulation of serine-type peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NI L 301

Chain	Residue
H	HIS119
L	ASP1
L	LYS9
L	HOH302
L	HOH303
L	HOH304

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA H 302

Chain	Residue
H	HOH337
H	HOH377
H	HOH412
H	ARG221
H	LYS224
H	HOH317

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
H	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:17685615, ECO:0000269|PubMed:8251938

Chain	Residue	Details
I	TYS63
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000250

Chain	Residue	Details
I	THR45

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