2PE4

Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hyaluronidase-1	polymer	424	47414.4	1	UniProt (Q12794) Pfam (PF01630) In PDB	Homo sapiens (human)	Hyal-1, Hyaluronoglucosaminidase-1, LUCA-1
2	B	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	A	ACETATE ION	non-polymer		59.0	7	Chemie (ACT)
5	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6		water	water		18.0	335	Chemie (HOH)

Sequence modifications

A: 22 - 435 (UniProt: Q12794)

PDB	External Database	Details
Arg 20	-	cloning artifact
Ser 21	-	cloning artifact
Thr 436	-	cloning artifact
Gly 437	-	cloning artifact
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	47414.4
Branched	Number of molecules	2
	Total formula weight	1497.4
Non-Polymers*	Number of molecules	8
	Total formula weight	505.4
All*	Total formula weight	49417.2

*Water molecules are not included.