2PE4
Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hyaluronidase-1 | polymer | 424 | 47414.4 | 1 | UniProt (Q12794) Pfam (PF01630) | Homo sapiens (human) | Hyal-1, Hyaluronoglucosaminidase-1, LUCA-1 |
| 2 | B (B) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G09724ZC) | |||
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E, F, G, H... (A) | ACETATE ION | non-polymer | 59.0 | 7 | Chemie (ACT) | |||
| 5 | K (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | L (A) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
A: 22 - 435 (UniProt: Q12794)
| PDB | External Database | Details |
|---|---|---|
| Arg 20 | - | cloning artifact |
| Ser 21 | - | cloning artifact |
| Thr 436 | - | cloning artifact |
| Gly 437 | - | cloning artifact |
| His 438 | - | expression tag |
| His 439 | - | expression tag |
| His 440 | - | expression tag |
| His 441 | - | expression tag |
| His 442 | - | expression tag |
| His 443 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47414.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1497.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 505.4 | |
| All* | Total formula weight | 49417.2 |
