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2PE4

Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0001618molecular_functionvirus receptor activity
A0004415molecular_functionhyalurononglucosaminidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005975biological_processcarbohydrate metabolic process
A0006027biological_processglycosaminoglycan catabolic process
A0006954biological_processinflammatory response
A0008152biological_processmetabolic process
A0009615biological_processresponse to virus
A0010634biological_processpositive regulation of epithelial cell migration
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0030207biological_processchondroitin sulfate catabolic process
A0030212biological_processhyaluronan metabolic process
A0030213biological_processhyaluronan biosynthetic process
A0030214biological_processhyaluronan catabolic process
A0030307biological_processpositive regulation of cell growth
A0030308biological_processnegative regulation of cell growth
A0031410cellular_componentcytoplasmic vesicle
A0036117cellular_componenthyaluranon cable
A0036120biological_processcellular response to platelet-derived growth factor stimulus
A0043202cellular_componentlysosomal lumen
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045766biological_processpositive regulation of angiogenesis
A0045785biological_processpositive regulation of cell adhesion
A0045927biological_processpositive regulation of growth
A0046677biological_processresponse to antibiotic
A0050501molecular_functionhyaluronan synthase activity
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051216biological_processcartilage development
A0052757molecular_functionchondroitin hydrolase activity
A0060272biological_processembryonic skeletal joint morphogenesis
A0070062cellular_componentextracellular exosome
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0071467biological_processcellular response to pH
A0071493biological_processcellular response to UV-B
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1900106biological_processpositive regulation of hyaluranon cable assembly
Functional Information from PROSITE/UniProt
site_idPS01186
Number of Residues12
DetailsEGF_2 EGF-like domain signature 2. CrCypGWqapw....C
ChainResidueDetails
ACYS418-CYS429

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AGLU131

site_idSWS_FT_FI2
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17503783
ChainResidueDetails
AASN99
AASN216
AASN350

218853

PDB entries from 2024-04-24

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