2PE4

Structure of Human Hyaluronidase 1, a Hyaluronan Hydrolyzing Enzyme Involved in Tumor Growth and Angiogenesis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0001618	molecular_function	virus receptor activity
A	0004415	molecular_function	hyalurononglucosaminidase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0005975	biological_process	carbohydrate metabolic process
A	0006027	biological_process	glycosaminoglycan catabolic process
A	0006954	biological_process	inflammatory response
A	0009615	biological_process	response to virus
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030207	biological_process	chondroitin sulfate catabolic process
A	0030212	biological_process	hyaluronan metabolic process
A	0030214	biological_process	hyaluronan catabolic process
A	0030307	biological_process	positive regulation of cell growth
A	0030308	biological_process	negative regulation of cell growth
A	0031410	cellular_component	cytoplasmic vesicle
A	0036117	cellular_component	hyaluranon cable
A	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
A	0043202	cellular_component	lysosomal lumen
A	0044344	biological_process	cellular response to fibroblast growth factor stimulus
A	0045766	biological_process	positive regulation of angiogenesis
A	0045785	biological_process	positive regulation of cell adhesion
A	0046677	biological_process	response to antibiotic
A	0051216	biological_process	cartilage development
A	0052757	molecular_function	chondroitin hydrolase activity
A	0060272	biological_process	embryonic skeletal joint morphogenesis
A	0070062	cellular_component	extracellular exosome
A	0071347	biological_process	cellular response to interleukin-1
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0071467	biological_process	cellular response to pH
A	0071493	biological_process	cellular response to UV-B
A	1900106	biological_process	positive regulation of hyaluranon cable assembly

Functional Information from PROSITE/UniProt

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CrCypGWqapw....C

Chain	Residue	Details
A	CYS418-CYS429

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305

Chain	Residue	Details
A	GLU131

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17503783

Chain	Residue	Details
A	ASN99
A	ASN216
A	ASN350

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1fcq

Chain	Residue	Details
A	GLU131
A	ASP129
A	TYR247
A	TRP321
A	TYR202

---